La cátedra de Alergia ha apoyado la investigación del grupo RD16/0006/0032 de la RED ARADYAL (Asma, Reacciones Adversas a Fármacos y Alergia) durante la duración de la misma hasta 2023.

‘ARADyAL’, una red para la investigación del asma y reacciones adversas a fármacos y alérgicas – Universidad de Málaga (uma.es)

ARADyAL: The Spanish Multidisciplinary Research Network for Allergic Diseases – PubMed (nih.gov)

También apoya al Grupo de investigación del Instituto de Investigación del Hospital General Universitario de Alicante (ISABIAL)

https://isabial.es

El grupo ALERGIAS de ISABIAL está constituido por:

Coordinador del Grupo: F. Javier Fernández Sánchez CATEDRÁTICO DE MEDICINA. ALERGÓLOGO.

Componentes:

Investigador contratado a tiempo parcial por la Cátedra de alergia:

Líneas de investigación actuales y de futuro:

LTP de melocotón y otros alérgenos con el almendro y otros pólenes como las gramíneas: Sensibilización e inmunoterapia
Rinitis alérgica local y conjuntivitis alérgica local
FPIES (Food protein-induced Enterocolitis)

Desarrollo de investigación clínica con quimioterápicos, y biológicos. También Betalactámicos y Cefalosporinas.
Hipersensibilidad a venenos de himenópteros (abejas y avispas)

Propuestas de futuro:
 
Colaboración con otros grupos mediante Biobanco del Hospital G. Universitario de Alicante-Instituto ISABIAL: Muestras de suero y otras secreciones.
 
Desarrollo de investigación propia en FPIES.
 
Estudio de otros alérgenos relacionados con pólenes y frutas como el Almendro en colaboración con Departamento de Agroquímica de la Universidad de Alicante. Y sobre gramíneas con el Grupo de Ciudad Real y el anterior grupo.
 
Unidad de desensibilización a quimioterápicos y biológicos.
 
Creación dentro del Dpto. de Medicina Clínica del Grupo de METAANÁLISIS.
 
Posibilidad de Ayudas para cursar Máster de Investigación en Medicina Clínica a distancia en la UMH.

Publicaciones de los miembros de la Cátedra de Alergia
Jimenez-Rodriguez TW, De las Vecillas L, Labella M, Lynch DM, Besz KM, Marquis k, Burgos A, Soriano-Gomis V, Lozano I, Montoyo-Antón RM, Marco de la Calle F, González.Delgado MP, Gutiérrez A, Montenegro E, Rodríguez F, Fernández-Sánchez FJ, Castell M.  Differential presentation of hypersensitivity reactions to carboplatin and oxaliplatin: Phenotypes, endotypes, and management with desensitization. Allergy. 2023;00:1–11.
Doi: 10.1111/all.15940

Torres-Rojas, I, Perez-Alzate, D, Somoza, ML, Pfeifer, APM, Diaz, EH, Jimenez-Rodriguez, TW, Sanchez, JF. Ruano, FJ. Blanca, M, Blanca-Lopez, N. Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins. Allergy Asthma & Immunology Research 2023; 15 (2):201-213.
Doi:10.4168/aair.2023.15.2.201.

Jimenez-Rodriguez TW, Manuel Marco de la Calle F, Lozano-Cubo I, Montoyo-Anton RA, Soriano-Gomis V, Gonzalez-Delgado P, Burgos-San José A, Climent-Ballester S, Martínez-Banaclocha N, Fernández-Sanchez J. Converter Phenotype: A New Profile That Is Not Exclusive to Taxanes. Front Allergy. 2022 Jan 12;2:785259. PMID: 35387038
Doi: 10.3389/falgy.2021.785259.

Quan PL, Sabaté-Brescó M, D’Amelio CM, Pascal M, García BE, Gastaminza G, Blanca-López N, Alvarado MI, Fernández J, Moya C, Bartra J, Ferrer M, Goikoetxea MJ. Validation of a commercial allergen microarray platform for specific immunoglobulin E detection of respiratory and plant food allergens. Ann Allergy Asthma Immunol. 2022 Mar;128(3):283-290.e4. PMID: 34863952
Doi: 10.1016/j.anai.2021.11.019.

Nieto A, Mazón Á, Nieto M, Ibáñez E, Jang DT, Calaforra S, Alba P, Pérez-Francés C, Llusar R, Montoro J, de Mateo A, Alamar R, El-Qutob D, Fernández J, Moral L, Toral T, Antón M, Andreu C, Ferrer Á, Flores IM, Cerdá N, Del Pozo S, Caballero R, Subiza JL, Casanovas M. First-in-human phase 2 trial with mite allergoids coupled to mannan in subcutaneous and sublingual immunotherapy. Allergy. 2022 Oct;77(10):3096-3107. PMID: 35570712
Doi: 10.1111/all.15374.

Somoza ML, Pérez-Sánchez N, Torres-Rojas I, Martín-Pedraza L, Blanca-López N, Victorio Puche L, Abel Fernández González E, López Sánchez JD, Fernández-Sánchez J, Fernández-Caldas E, Villalba M, Ruano FJ, Cornejo-García JA, Canto G, Blanca M. Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area. J Asthma Allergy. 2022 Sep 26;15:1359-1367. PMID: 36189188
Doi: 10.2147/JAA.S370279.

Ruano-Zaragoza M, Casas-Saucedo R, De la Cruz Martinez CA, Araujo-Sanchez G, Gelis S, González MF, San Bartolomé C, Pascal M, Jiménez-Rodriguez TW, Gonzalez-Delgado P, Fernandez-Sanchez J, Muñoz-Cano R, Bartra J. Advances in the understanding of the cofactor effect in lipid transfer protein food allergy: From phenotype description to clinical management. Allergy. 2022 Jun;77(6):1924-1926. PMID: 35322440.
Doi: 10.1111/all.15291. 

González-Delgado P, Muriel J, Jiménez T, Cameo JI, Palazón-Bru A, Fernández J. Food Protein-Induced Enterocolitis Syndrome in Adulthood: Clinical Characteristics, Prognosis, and Risk Factors. J Allergy Clin Immunol Pract. 2022 Sep;10(9):2397-2403. PMID: 35598865.
Doi: 10.1016/j.jaip.2022.05.006. 

García-Martín E, García-Menaya JM, Esguevillas G, Cornejo-García JA,  Doña I, Jurado-Escobar R, Torres MJ, Blanca-López N, Canto G, Blanca M, Laguna JJ, Bartra J, Rosado A, Fernández J, Cordobés C, Agúndez JAG. Deep sequencing of prostaglandin‐endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross‐reactive hypersensitivity to NSAID. Br J Pharmacol. 2021; 178: 1218– 1233.
https://doi.org/10.1111/bph.15366

Doña I, Blanca-López N, Boteanu C, Cueva-Oliver B, Fernández-Sánchez FJ, Gajate P, García-Avilés MC, García-Núñez I, Lobera T, Moreno E, Rojas P, Rosado A. Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Quinolones. J Investig Allergol Clin Immunol 2021; Vol. 31(4): 292-307.
Doi: 10.18176/jiaci.0669.

Macías Y, García Menaya JM, Martí M. CordobésC, Jurado Escobar R,         Cornejo García JA, Torres MJ, Blanca López N, Canto G, Blanca M, Laguna JJ, Bartra J, Rosado A, Fernandez J, García Martín E, Agúndez JA. Lack of Major Involvement of Common CYP2C Gene Polymorphisms in the Risk of Developing Cross-Hypersensitivity to NSAIDs. Frontiers in Pharmacology. 12, pp. 648262. 2021. ISSN 1663-9812.
Doi: 10.3389/fphar.2021.648262.

Prieto-Moreno Pfeifer A, Torres Rojas I, Pérez Alzate D, Somoza ML, Haroun Díaz E, Ruano Pérez FJ, Jiménez Rodríguez TW; Fernández Sánchez J, BlancaM, Canto Diez G, Blanca López N. Patterns of response and drugs involved in hypersensitivity reactions to beta-lactams in children. Pediatric Allergy and Immunology. 32 – 8, pp. 1788 – 1795. 2021. ISSN 0905-6157.
Doi: 10.1111/pai.13608.

Somoza ML, Prieto-Moreno Pfeifer A, Martín Pedraza L, Victorio Puche L, Esteban Rodríguez A, López Rodríguez N, Fernández González AE, Fernández Caldas E, MoránMorales M, Fernández Sánchez J, López Sánchez JD, Subiza Garrido-LestacheJL Cantó G, Blanca M. Skin Testing With Peach Peel Extract Versus Serum IgE to Pru p 3 as a Stronger Predictor of Peach-Induced Anaphylaxis. Allergy Asthma & Immunology Research. 13 – 6, pp. 922 – 932. 2021. ISSN 2092-7355.
Doi: 0.4168/aair.2021.13.6.922.

Somoza ML, Pérez Sánchez N, Victorio Puche L, Martín Pedraza L, Esteban Rodríguez A, Blanca López N, Fernández González EA, Ruano Zaragoza M, Prieto-Moreno Pfeifer A, Fernández Caldas E, Morán Morales M, Fernández Sánchez J, López Sánchez JD, Jiménez Rodríguez TW, Subiza Garrido-Lestache JL, Cantó Diez G, BlancaM, Cornejo García JA. Subjects develop tolerance to Pro p 9: A large study group from a peach exposed population. PLoS One. 16 – 8, 2021.
Doi: 10.1371/journal.pone.0255305.

Fernandez J, Ruano-Zaragoza M, Blanca-Lopez N. Omalizumab and other biologics in drug desensitization. Curr Opin Allergy Clin Immunol. 2020 Aug;20(4):333-337.
Doi: 10.1097/ACI.0000000000000648. PMID: 32398420.

Soriano-Gomis V, Cabrera-Beirouty R, Serrano-Delgado P, Jimenez-Rodriguez TW, Blanca M, Fernandez J. Epidemiology of Hymenoptera venom allergy in the Valencia Fire Brigade (Spain). J Allergy Clin Immunol Pract. 2021; 9(2):1037-38. PMID: 33038590.
Doi: 10.1016/j.jaip.2020.09.038. 

Ruano-Zaragoza M. Somoza ML, Jimenez-rodriguez TW, Sorianoc Gomis V, Gonzalez-Delgado P, Esteban-Rodriguez A, Plazón Bru A, Blanca M, Fernandez J. Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients. International Archives of Allergy and Immunology. 2020 Dec 18;1-8. PMID: 33341818
Doi: 10.1159/000511977

Cabanas, R, Ramirez, E, Sendagorta, E, Alamar, R, Barranco, R, Blanca-Lopez, N, Dona, I, FERNANDEZ SANCHEZ, F, Garcia-Nunez, I, Garcia-Samaniego, J, Lopez-Rico, R. Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome. J Investig Allergol Clin Immunol. 2020;30(4):229-253. PMDI: 31932268.
Doi: 10.18176/jiaci.0480.

Jimenez-Rodriguez TW, Blanca-Lopez N, Ruano-Zaragoza M, Esteban-Rodriguez A, Riera-Sendra G, Palazón Bru A, Blanca M, Ramos Rincón JM, Fernández-Sánchez, J. Allergological Study of 565 Elderly Patients Previously Labeled as Allergic to Penicillins. J Asthma Allergy. 2019; 12: 421–435. PMID: 31853189
Doi: 10.2147/JAA.S232787

Gomez, E, Ruano-Zaragoza, M, Somoza, M, Fernandez, J, Blanca-Lopez, N. Role of T cells in non-immediate drug allergy reactions. Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):294-301. PMID: 31135394

López-Bru D, Palazón-Bru A, Folgado-de la Rosa DM, Gil-Guillén VF 2. UMH A scoring system to predict recurrence in patients with differentiated thyroid cancer Clin Otolaryngol. 2019 Jan;44(1):26-31. PMID: 30220101

Purificación Gonzalez-Delgado, Esther Caparrós, M. Victoria Moreno, Begoña Cueva, and Javier Fernández. Food protein induced enterocolitis-like syndrome in a population of adolescents and adults caused by seafood. J Allergy Clin Immunol Pract. 2019 7(2):670-672. PMID: 30075344.
Doi: 10.1016/j.jaip.2018.07.028 

Tabar AI, Prieto L, Alba P, Nieto A, Rodríguez M, Torrecillas M, Huertas B, Gómez E, Fernández FJ, Blanca M, Rodríguez D, Palacios R, “Double-blind, randomised, placebocontrolled trial of allergen-specific immunotherapy with major allergen Alt a 1”. Journal of Allergy and Clinical Immunology 2019 Jul;144(1):216-223.e3. PMID: 30879998.
Doi: 10.1016/j.jaci.2019.02.029.
 
Martínez-Díaz AM, Palazón-Bru A, Folgado-de la Rosa DM, Ramírez-Prado D, Navarro-Juan M, Pérez-Ramírez N, Gil-Guillén VF 2. UMH A one-year risk score to predict all-cause mortality in hypertensive inpatients Eur J Intern Med. 2018 Jul 12.pii: S0953-6205(18)30282-6.
Doi: 10.1016/j.ejim.2018.07.010. PMID: 30007839
 
Jover-Esplá AG, Palazón-Bru A, Folgado-de la Rosa DM, de Juan-Herrero J, Gil-Guillén VF. 2. UMH A scoring system to predict 5-year mortality in patients diagnosed with laryngeal glottic cancer Eur J Cancer Care (Engl). 2018 Jul;27(4):e12860.
Doi: 10.1111/ecc.12860 PMID: 29870075
 
García-Macías JA, Palazón-Bru A, Carbonell-Torregrosa MÁ, Navarro-Juan M, Gil-Guillén VF. 2. UMH . Therapeutic inertia in anti-platelet therapy in patients with a cardiovascular event attended in an emergency department Curr Med Res Opin. 2018 May 21:1-5.
Doi: 10.1080/03007995.2018.1469480 PMID: 29690773
 
«Pérez-Tomás C, Gómez-Pérez L, Romero-Maroto J, Palazón-Bru A, Navarro-Cremades F, Cortés-Castell E». 2. UMH Sexual Quality of Life After Treatment of Stress Urinary Incontinence With Adjustable Tension-free Mesh System in Women Who Were Sexually Active Before Surgery Urology. 2018 May;115:76-81.
Doi:10.1016/j.urology.2018.02.031 PMID: 29522866
 
Carbayo Herencia JA, Simarro Rueda M, Palazón Bru A, Molina Escribano F,Ponce García I, Artigao Ródenas LM, Caldevilla Bernardo D, Divisón Garrote JA,Gil Guillén VF; (GEVA) 2. UMH Evaluation of non-HDL cholesterol as a predictor of non-fatal cardiovascular events in a prospective population cohort Clin Investig Arterioscler. 2018 Mar – Apr;30(2):64-71.
Doi: 10.1016/j.arteri.2017.10.003 PMID: 29395492
 
Palazón-Bru A, Rizo-Baeza MM, Martínez-Segura A, Folgado-de la Rosa DM, Gil-Guillén VF, Cortés-Castell E 2. UMH Screening Tool to Determine Risk of Having Muscle Dysmorphia Symptoms in Men Who Engage in Weight Training at a Gym. Clin J Sport Med. 2018 Mar;28(2):168-173.
Doi: 10.1097/JSM.0000000000000422 PMID: 29271781
 
Salinas, Maria; Flor, Emilio; Lopez-Garrigos, Maite; et al. 2. UMH Computer-assisted interventions in the clinical laboratory process improve the diagnosis and treatment of severe vitamin B12 deficiency Clinical chemistry and laboratory medicine Published: 2018-May-01. Doi: 10.1515/cclm-2017-1116 PMID: 29715174.

Salinas, Maria; Lopez-Garrigos, Maite; Flores, Emilio; et al. 2. UMH Glycated hemoglobin: A powerful tool not used enough in primary care Journal of Clinical Laboratory analysis Volume: 32 Issue: 3 Published: 2018.
Doi: 10.1002/jcla.22310 PMID: 28857364
 
Salinas, M.; Lopez-Garrigos, M.; Flores, E.; et al. 2. UMH Procalcitonin in the ED: A potential expensive over-request that can be modulated through institutional protocols American Journal of Emergency Medicine Volume: 36 Issue: 1 Pages: 158-160 Published: 2018
Doi: 10.1016/j.ajem.2017.07.033 PMID: 28768585
 
Salinas, Maria; Lopez-Garrigos, Maite; Flores, Emilio; et al. 2. UMH Request Pattern, Pre-Analytical and Analytical Conditions of Urinalysis in Primary Care: Lessons from a One-Year Large-Scale Multicenter Study Clinical laboratory Volume: 64 Issue: 6 Pages: 983-989 Published: 2018-Jun-01
Doi: 10.7754/Clin.Lab.2018.171239 PMID: 29945335
 
Salinas, Maria; Lopez-Garrigos, Maite; Flores, Emilio; et al. 2. UMH Serum Uric Acid Laboratory Test Request Patterns in Primary Care: How Panels May Contribute to Overutilization and Treatment of Asymptomatic Patients Laboratory Medicine Volume: 49 Issue: 1 Pages: 55-58 Published: 2018
Doi: 10.1093/labmed/lmx075 6. PMID: 29220493
 
Salinas, Maria; Lopez-Garrigos, Maite; Flores, Emilio; et al.2. UMH Urinary albumin strip assay as a screening test to replace quantitative technology in certain conditions Clinical chemistry and laboratory medicine Published: 2018-Jul-19
Doi: 10.1515/cclm-2018-0546 PMID: 30024851
 
Salinas, M.; Flores, E.; Lopez-Garrigos, M.; et al. 2. UMH Vitamin B12 deficiency and clinical laboratory: Lessons revisited and clarified in seven questions International Journal of Laboratory Hematology Volume: 40 Pages: 83-88 Published: 2018
D0i: 10.1111/ijlh.12833 PMID: 29741251
 
Teodorikez Wilfox Jimenez Rodriguez; Marlene Garcia Neuer; Leila Alenazy; Mariana Castells. 1. DS Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers. Journal of Asthma and Allergy. 11, pp. 1 – 22. 2018 PMID: 29950872
 
Martínez-Márquez, A.; Morante-Carriel, J.A.; Palazon, J.; Bru-Martínez, R 3. UA Rosa hybrida orcinol O-methyl transferase-mediated production of pterostilbene in metabolically engineered grapevine cell cultures.New Biotechnology. 42, pp. 62 – 70. 2018. ISSN 1871-6784. Doi: 10.1016/j.nbt.2018.011 PMID: 29477599
 
Belchí-Navarro, S.; Almagro, L.; Bru-Martínez, R.; Pedreño, M.A. 3. UA Changes in the secretome of Vitis vinifera cv. Monastrell cell cultures treated with cyclodextrins and methyl jasmonate. Plant Physiology and Biochemistry (in press)
Doi:10.1016/j.plaphy.2018.11.007 PMID: 30448023
 
Campo P, Del Carmen Plaza-Seron M, Eguiluz-Gracia I, Verge J, Galindo L, Barrionuevo E, Fernandez J, Jurado R, Mayorga C, Torres MJ, Rondón C.1. DS Direct intranasal application of the solid phase of ImmunoCAP® increases nasal specific immunoglobulin E detection in local allergic rhinitis patients. Int Forum Allergy Rhinol. 2018 Jan;8(1):15-19.  
Doi: 10.1002/alr.22039. 29136342
 
Javier Fernandez & Inmaculada Doña 1. DS Diagnosing and managing patients with drug hypersensitivity Expert Rev Clin Immunol. 2018 Jan;14(1):29-41.
Doi: 10.1080/1744666X.2018.1410059. PMID: 29202594
 
Ramos-Rincón JM, Sempere-Selv T, Romero-Nieto M, Peris-García J, Martínez-de la Torre G, Harris M, Fernández-Sánche J. 2. UMH Pecha Kucha presentations by medical students in Spain. International Journal of Medical Education. 2018; 9:244-245. ISSN: 2042-6372.
Doi: 10.5116/ijme.5b92.52e3. PMID: 30244236
 
Purificación Gonzalez-Delgado, Esther Caparrós, M. Victoria Moreno, Begoña Cueva, and Javier Fernández 1. DS Foodproteineinducedenterocolitis-like syndrome in a population of adolescents and adults caused by seafood. J Allergy Clin Immunol Pract. 2018 Aug 1. pii: S2213-2198(18)30464-1.
Doi: 10.1016/j.jaip.2018.07.028. PMID: 30075344
 
Carlos Oeo-Santos; S Mas; Joaquin Quiralte; Carlos Colás; Miguel Blanca; Javier Fernández; Francisco Feo Brito; María Teresa Villalba; R Barderas. 1. DS A Hypoallergenic Polygalacturonase Isoform from Olive Pollen Is Implicated in Pollen-Pollen Cross-ReactivityInt Arch Allergy Immunol. 2018;177(4):290-301.
Ddoi: 10.1159/0004910 30173224